Lactate promotes cuproptosis in acute kidney injury by activating H3K18 lactylation-dependent upregulation of HSPA6 expression
The present study unveils a previously unidentified epigenetic pathway in AKI, whereby lactate-driven H3K18 lactylation transcriptionally activates HSPA6, consequently promoting cuproptosis and exacerbating renal damage. The "lactate-H3K18la-HSPA6" axis has been identified as a promising new target for therapeutic intervention in AKI.
Authors
- Jiazhao Fu
- Mingxing Sui (ORCID: https://orcid.org/0000-0002-7981-794X)
- Hanlan Lu
- Wenyu Zhao
- Yanhua Li
- Junhao Yu (ORCID: https://orcid.org/0009-0008-4977-0408)
- Yuhong Li
- Li Zeng
Institutions
- Second Military Medical University (CN)
- Changhai Hospital (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.lfs.2026.124244
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00