Drug-induced male infertility: a real-world study using FAERS and EudraVigilance databases
This pharmacovigilance study identified 19 high-risk drugs for male infertility across hormonal agents, antineoplastic drugs, and antidepressants. These findings underscore pre-prescription, risk-stratified fertility counseling for reproductive-age males, prioritizing sperm cryopreservation before chemotherapy and considering it selectively for 5α-reductase inhibitors, testosterone, or antidepressants.
Authors
- ShengJing Liu (ORCID: https://orcid.org/0000-0003-2828-0959)
- Jing He
- Zhuozhi Gong
- Qiujian Feng
- Dong Liu
Institutions
- Xiyuan Hospital (CN)
- China Academy of Chinese Medical Sciences (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fphar.2026.1765071
- Citations
- 2
- Primary Topic
- Pharmacovigilance and Adverse Drug Reactions
- Type
- article
- Field-Weighted Citation Impact
- 67.27
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Ningxia Province
- U.S. Food and Drug Administration