Association analysis of Mycoplasma pneumoniae 23S rRNA gene mutation with refractory Mycoplasma pneumoniae pneumonia in children
The widespread macrolide resistance in M. pneumoniae (76.6% in this cohort) was associated with point mutations at the A2063G and/or A2064G loci in the 23S rRNA gene. The development of RMPP is linked to macrolide-resistant mutations, duration of fever and D-dimer levels. D-dimer emerged as the most predictive risk factor.
Authors
- Wei Gao
- Xuan Tang
- Aimin Li
- Wen heng Li
- Xiaoyu Xiong
Institutions
- Xianning Central Hospital (CN)
- Hubei University of Science and Technology (CN)
- Jingzhou Central Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1371/journal.pone.0341580
- Citations
- 1
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 31.52