Impact of newer antihyperglycemic agents on hepatic complications: A systematic review and meta-analysis of data from 5.3 million patients with type 2 diabetes mellitus
GLP-1 RAs and SGLT-2 inhibitors were associated with hepatoprotective effects compared with other glucose-lowering therapies in patients with T2DM, with GLP-1 RAs showing additional benefits in chronic liver disease. These findings provide evidence on the relationships between antidiabetic drug classes and liver-related outcomes in patients with T2DM and may inform clinical decision-making.
Authors
- Jing Ju (ORCID: https://orcid.org/0000-0002-1024-2850)
- J.W. Yang
- Jihyun An
- Seungbong Han
- Yeongseok Hwang
- Ju Hyun Shim
Institutions
- Ulsan College (KR)
- Korea University (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Hanyang University Guri Hospital (KR)
Publication Details
- Journal
- Hepatology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1097/hep.0000000000001695
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00