Effect of prophylactic antibiotics on days of antibiotic spectrum coverage in comatose post-cardiac arrest patients: a secondary analysis of PROTECT
DASC post intervention was lower in the ceftriaxone group, representing less antibiotic exposure following the intervention. There was no correlation between new ARGs and DASC. Further study is needed to understand the relationship between antibiotic prophylaxis, subsequent antibiotic exposure and resistome changes in the critically ill.
Authors
- Douglas B. Sawyer (ORCID: https://orcid.org/0000-0002-5998-4230)
- Richard R. Riker (ORCID: https://orcid.org/0000-0002-0682-6204)
- Kristin M. Burkholder (ORCID: https://orcid.org/0000-0002-9808-2483)
- David J. Gagnon (ORCID: https://orcid.org/0000-0002-9888-7265)
- Teresa L May
- Alexandra J Weissman
- Clifton W Callaway
- David B Seder
- Daniel J Diekema
Institutions
- Tufts University (US)
- Maine Medical Center (US)
- University of Pittsburgh (US)
- University of New England (US)
- MaineHealth (US)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1093/jacamr/dlag001
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of General Medical Sciences