Autoimmune Protocol Diet (AIP) for Food Allergies: A Novel Immunonutrition Approach

The prevalence of allergies is increasing worldwide. In addition to pharmacological treatment, dietary management represents an established component of food allergy care. Elimination diets have long been recognized as an effective therapy for certain conditions, including food allergies. The Autoimmune Protocol (AIP) diet, a restrictive elimination diet originally developed for patients with autoimmune diseases, has gained popularity recently. Its underlying rationale, centered on immune regulation, intestinal epithelial barrier function, and gut dysbiosis, suggests potential relevance to food allergies. Moreover, the AIP excludes most of the major food allergens, which may support symptom reduction and facilitate the identification of individual dietary triggers. The role of histamine in allergic responses further highlights the AIP’s potential applicability in cases of histamine intolerance, where reducing the overall histamine burden could be beneficial. This narrative review aimed to synthesize the limited available evidence on the AIP and explore its potential implementation, mechanisms, and limitations in the context of food allergies.