PTCOG Ocular Survey – Perspective on Ocular Particle Therapy: Current Practices and Emerging Trends
Common protocols in dosimetry, dose, and fractionation have largely been adopted worldwide, while variability persists in planning, quality assurance, and delivery workflows. The obsolescence of dedicated ocular proton systems and key planning tools, and a lack of standardization, remain as pressing challenges. The adoption of non-dedicated high-energy systems on gantries and integration into multipurpose treatment environments enhances OPT accessibility, but this transition requires ongoing critical evaluation of dosimetric trade-offs and clinical outcomes. Multicenter collaboration, technological innovation, and clinical validation are essential to continued assurance of the safe and effective delivery of OPT worldwide.
Authors
- A. Denker (ORCID: https://orcid.org/0009-0000-5992-2403)
- Petra Trnková (ORCID: https://orcid.org/0000-0002-0347-2981)
- Alexei Trofimov (ORCID: https://orcid.org/0000-0003-0148-9699)
- Jatinder Saini (ORCID: https://orcid.org/0009-0002-6280-7179)
- H. Shih
- Jan Hrbáček (ORCID: https://orcid.org/0000-0002-4243-8698)
- E. Fleury (ORCID: https://orcid.org/0000-0002-8614-4624)
- R Slopsema (ORCID: https://orcid.org/0000-0001-9112-1980)
- Anaïs Groulier
- Juliette Thariat (ORCID: https://orcid.org/0000-0003-4755-496X)
- Andrzej Kacperek (ORCID: https://orcid.org/0000-0002-2434-2924)
- A. Mazal (ORCID: https://orcid.org/0000-0003-1391-8446)
- Linda Mortimer
- Jan-Willem M. Beenakker
- R. Dendale
- Marie Vidal
- Kavita K. Mishra
Institutions
- Centre National de la Recherche Scientifique (FR)
- Harvard University (US)
- Emory University (US)
- University of California, San Francisco (US)
- University of Washington (US)
- Leiden University Medical Center (NL)
- Helmholtz-Zentrum Berlin für Materialien und Energie (DE)
- Paul Scherrer Institute (CH)
- Clatterbridge Cancer Centre NHS Foundation Trust (GB)
- Massachusetts General Hospital (US)
- Hospital Universitario Quirónsalud Madrid (ES)
- Laboratoire de Physique Corpusculaire de Caen (FR)
- Centre François Baclesse (FR)
- Erasmus MC Cancer Institute (NL)
- Centre Antoine Lacassagne (FR)
- Czech Technical University in Prague (CZ)
- University College London (GB)
- Charité - Universitätsmedizin Berlin (DE)
- Institut Curie (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- International Journal of Particle Therapy
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.ijpt.2026.101300
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Florida Department of Health
- Northwestern University
- University College London
- University of California, San Francisco
- University of Florida Health