Cancer Incidence and Mortality With Aspirin in Older Adults
In this study, over a median of 8.6 years, LDA was not associated with incident cancer among older adults, but cancer mortality risk was significantly elevated. However, the elevated cancer mortality risk seen with aspirin for participants in the RCT period did not persist into the post-RCT observation period, suggesting no legacy effect.
Authors
- John Raymond Zalcberg (ORCID: https://orcid.org/0000-0002-6624-0782)
- Anne M. Murray (ORCID: https://orcid.org/0000-0002-2787-8433)
- Lucy Gately (ORCID: https://orcid.org/0000-0002-3003-3175)
- Aaron Kent
- Erica Warner
- Emma Hiscutt (ORCID: https://orcid.org/0000-0002-3914-1084)
- Galina Polekhina (ORCID: https://orcid.org/0000-0001-9535-9291)
- Brenda Kirpach (ORCID: https://orcid.org/0000-0002-5402-2227)
- J. Tie
- Jeremy Millar (ORCID: https://orcid.org/0000-0001-8202-8602)
- Suzanne Gaye Orchard (ORCID: https://orcid.org/0000-0003-0211-3183)
- Asad Umar
- Wendy B. Bernstein
- FA Macrae
- Wee Loon Ong
- Joanne Ryan (ORCID: https://orcid.org/0000-0002-7039-6325)
- Leslie Ford
- Andrew T. Chan
- Robyn L. Woods
- Mark Nelson
- Raj C. Shah
- John J. McNeil
- G. J. van Londen
- Peter Gibbs
- Luz Maria Rodriguez
- Rory Wolfe
- Victoria Mar
Institutions
- Rush University Medical Center (US)
- University of Tasmania (AU)
- The Royal Melbourne Hospital (AU)
- Harvard University (US)
- Uniformed Services University of the Health Sciences (US)
- The University of Melbourne (AU)
- University of Pittsburgh (US)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Walter Reed National Military Medical Center (US)
- University of Minnesota System (US)
- Peter MacCallum Cancer Centre (AU)
- The Alfred Hospital (AU)
- Massachusetts General Hospital (US)
- Berman Center for Outcomes and Clinical Research (US)
- National Cancer Institute (US)
- Alfred Health (AU)
- Monash University (AU)
- The University of Adelaide (AU)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1001/jamaoncol.2025.6196
- Primary Topic
- Antiplatelet Therapy and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00