Retinal and Choriocapillaris Thickness and Age in Macaques in Development and Aging
Cynomolgus macaques undergo thickening of multiple retinal layers through their juvenile stage. Afterward, macaques undergo thinning of multiple retinal layers with age, suggesting aging-related changes. The increase in choriocapillaris thickness with age in both macaques and humans suggest remodeling due to aging. Cynomolgus macaques represent a valuable NHP model for studying developmental- and aging-related retinal/subretinal changes.
Authors
- Xialin Liu
- Y. Cao
- Kaoru Ri (ORCID: https://orcid.org/0009-0004-9315-1912)
- Folahan Adesola Ibukun
- Le Shi (ORCID: https://orcid.org/0000-0003-4827-4003)
- Xiangrong Kong (ORCID: https://orcid.org/0009-0000-2340-943X)
- Elia J. Duh
- Charles Eberhart
- Ziqi Yang
- Sophia Liang
- Shuxin Fan
- Haining Lu
- Wei Yi
Institutions
- Johns Hopkins University (US)
- Sun Yat-sen University (CN)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1167/iovs.67.1.60
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- National Natural Science Foundation of China
- National Institutes of Health
- Guangzhou Municipal Science and Technology Project