Individualized Atrophy‐Based Prediction of Dementia Progression in Familial Frontotemporal Lobar Degeneration With Bayesian Linear Mixed‐Effects Modeling
Bayesian-modeled individualized atrophy scores predict dementia progression among asymptomatic f-FTLD mutation carriers and may have increased utility compared with other structural imaging methods when studying individuals over shorter timeframes that align with clinical trial design. ANN NEUROL 2026.
Authors
- Hilary W. Heuer (ORCID: https://orcid.org/0000-0002-3776-1685)
- Adam L. Boxer (ORCID: https://orcid.org/0000-0002-1215-5064)
- Annie L Clark
- Shubir Dutt (ORCID: https://orcid.org/0000-0002-8408-2220)
- Marijne Vandebergh (ORCID: https://orcid.org/0000-0001-9645-2615)
- Yann Cobigo (ORCID: https://orcid.org/0000-0002-0354-4092)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Phoebe H. Foster (ORCID: https://orcid.org/0000-0001-6300-6598)
- M Otto
- Lucy L. Russell
- Brian S. Appleby (ORCID: https://orcid.org/0000-0003-2275-3292)
- J Levin
- Bayram Ece
- Gabriel C. Léger (ORCID: https://orcid.org/0000-0001-7900-3957)
- James Rowe (ORCID: https://orcid.org/0000-0003-4710-4694)
- Amy Wolf
- Edward D Huey
- Simon Ducharme
- J. D. Rohrer
- Walter K Kremers
- Maria Luisa Gorno‐Tempini
- Dana Leichter
- Molly Olzinski
- Irene Litvan
- Raquel Sánchez‐Valle
- Fermin Moreno
- David M Cash
- Nupur Ghoshal
- Leah K. Forsberg
- Harro Seelaar
- Adam M. Staffaroni
- Alexander Gerhard
- Isabel Santana
- Caroline Graff
- Rik Vandenberghe
- Joel H. Kramer
- John C. van Swieten
- Eve Ferry‐Bolder
- David Clark
- Chris R. Butler
- Ian M. Grant
- Pietro Tiraboschi
- William W. Seeley
- Barbara Borroni
- Bradford Dickerson
- Ian R. Mackenzie
- Eliana Marisa Ramos
- Lawrence S. Honig
- Lize C. Jiskoot
- Douglas R. Galasko
- Neill Graff‐Radford
- Rosa Rademakers
- Robert Laforce
- Kejal Kantarci
- David John Irwin
- Justin Y. Kwan
- Mario Masellis
- Daniela Galimberti
- Chadwick M. Hales
- Bruce L. Miller
- John Kornak
- Rhian S. Convery
- Ging‐Yuek Hsiung
- Bradley F. Boeve
- Andrea Bozoki
- Kimiko Domoto‐Reilly
- Matthis Synofzik
- Elizabeth Finger
- Sandro Sorbi
- Mario F. Mendez
- Howard J. Rosen
- Isabelle Le Ber
- Maria Carmela Tartaglia
- Peter Pressman
- Belen Pascual
- Martina Bocchetta
- Aaron Ritter
- Alexandre de Mendonça
- R. Ryan Darby
- Allison Snyder
- FTD Prevention Initiative (FPI) investigators
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Western University (CA)
- Indiana University Health (US)
- Montreal Neurological Institute and Hospital (CA)
- Houston Methodist (US)
- Sunnybrook Health Science Centre (CA)
- Karolinska University Hospital (SE)
- University of Lisbon (PT)
- University of British Columbia (CA)
- University of Antwerp (BE)
- Emory University (US)
- University of California, Los Angeles (US)
- University of Toronto (CA)
- University of Milan (IT)
- Universität Ulm (DE)
- Vanderbilt University (US)
- University of Washington (US)
- Washington University in St. Louis (US)
- University of Cambridge (GB)
- Douglas Mental Health University Institute (CA)
- Lou Ruvo Brain Institute (US)
- Instituto de Salud Carlos III (ES)
- German Center for Neurodegenerative Diseases (DE)
- Jacksonville College (US)
- Erasmus MC (NL)
- WinnMed (US)
- Cambridge University Hospitals NHS Foundation Trust (GB)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- University of Manchester (GB)
- University of Alabama at Birmingham (US)
- University of California San Diego (US)
- Sorbonne Université (FR)
- University of Oxford (GB)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Massachusetts General Hospital (US)
- Behavioral Pharma (United States) (US)
- Biogipuzkoa Health Research Institute (ES)
- University Memory and Aging Center (US)
- Alzheimer’s Disease Neuroimaging Initiative (US)
- National Institute of Neurological Disorders and Stroke (US)
- Occupational Cancer Research Centre (CA)
- Munich Cluster for Systems Neurology (DE)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Don Carlo Gnocchi Foundation (IT)
- Essen University Hospital (DE)
- Pitié-Salpêtrière Hospital (FR)
- Mayo Clinic in Arizona (US)
- UK Dementia Research Institute (GB)
- Klinikum Arnsberg (DE)
- VIB-UAntwerp Center for Molecular Neurology (BE)
- Donostiako Unibertsitate Ospitalea (ES)
- Hertie Institute for Clinical Brain Research (DE)
- Onkologikoa (ES)
- Mayo Clinic in Florida (US)
- Northwestern Medicine (US)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- VIB-KU Leuven Center for Brain & Disease Research (BE)
- Institute of Neurobiology (BG)
- Ferrari (Italy) (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Université Laval (CA)
- University of Florence (IT)
- University College London (GB)
- Imperial College London (GB)
- McGill University (CA)
- Indiana University – Purdue University Indianapolis (US)
- Case Western Reserve University (US)
- University of Duisburg-Essen (DE)
- University of Coimbra (PT)
- Columbia University (US)
- University of Pennsylvania (US)
- University of Brescia (IT)
- University of Tübingen (DE)
- Ludwig-Maximilians-Universität München (DE)
- Erasmus University Rotterdam (NL)
- University of Colorado Denver (US)
- KU Leuven (BE)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1002/ana.78167
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Center for Advancing Translational Sciences