Isolated Paramedian Pontine Reticular Formation (PPRF) syndrome in AQP4 antibody–positive neuromyelitis optica spectrum disorder: a case report
This is the first documented case of isolated PPRF syndrome in AQP4 antibody-positive NMOSD. The findings expand the known phenotypic spectrum of NMOSD and highlight the importance of considering NMOSD, with targeted AQP4 antibody testing, in patients presenting with isolated PPRF syndrome.
Authors
- Yujiro Higuchi (ORCID: https://orcid.org/0000-0002-5579-4384)
- Shota Hirakata
- Takahiro Hobara (ORCID: https://orcid.org/0009-0001-2900-182X)
- Yutaka Noguchi (ORCID: https://orcid.org/0000-0002-8017-8444)
- Hiroshi Takashima
- Satoshi Nozuma
- Manami Terahara
Institutions
- Kagoshima University (JP)
Publication Details
- Journal
- BMC Neurology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s12883-026-04670-6
- Primary Topic
- Ophthalmology and Eye Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00