Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease
Concordant severe impairment reflects a malignant profile linked to Aβ-related cognitive decline, while mild concordant cases show stable progression. Mismatch subgroups display distinct clinical patterns, underscoring the value of integrating imaging and motor features for early disease stratification.
Authors
- Paola Dimartino (ORCID: https://orcid.org/0000-0002-6521-1082)
- Luca Gallo (ORCID: https://orcid.org/0000-0002-2160-8467)
- Cinzia Zatti (ORCID: https://orcid.org/0009-0001-5648-0408)
- Marianna Inglese (ORCID: https://orcid.org/0000-0002-9154-8260)
- Alessandro Padovani (ORCID: https://orcid.org/0000-0002-0119-3639)
- Pierfrancesco Mitrotti (ORCID: https://orcid.org/0000-0003-3574-1290)
- Rachele Malito
- C Tassorelli
- Andrea Pilotto (ORCID: https://orcid.org/0000-0002-4639-4207)
- Micol Avenali
- Silvia P. Caminiti
- Alessandro Lupini
- Enza Maria Valente
- Chiara Meneghini
- Alice Galli
Institutions
- University of Rome Tor Vergata (IT)
- University of Pavia (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- University of Brescia (IT)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1002/acn3.70317
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Biogen
- Allergan
- Avid Radiopharmaceuticals