One-Pot Synthesis of Thiocyanato-Containing Polycyclic Indolones through Photo-Induced Cascade Radical Cyclization/Thiocyanation/Oxidation of <i>N</i> -Acylindoles
A photoinduced radical cascade cyclization/thiocyanation of <i>N</i>-acylindoles has been developed to obtain a series of thiocyanato-containing [1,3]oxazino[3,4-<i>a</i>]indolones and indolo[2,1-<i>b</i>]quinazolin-12(5<i>H</i>)-ones. A wide scope of substrates has been tolerated in moderate to good yields under mild and metal-free conditions.
Authors
- L. Chen
- Hongquan Yin
- Ruirui Hua (ORCID: https://orcid.org/0009-0000-6291-7277)
- Rui Tian (ORCID: https://orcid.org/0000-0003-2570-4322)
- Fuxue Chen (ORCID: https://orcid.org/0000-0001-5258-6806)
- Chukai Shao (ORCID: https://orcid.org/0000-0001-8633-9627)
- Kaixiang Liu
- Xiaowei Liu
- Xinzhe Zhao
Institutions
- Beijing Institute of Technology (CN)
- Shanghai Liangyou (China) (CN)
- Luye Pharma (China) (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1021/acs.joc.5c02353
- Primary Topic
- Quinazolinone synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00