Impact of recalcification on procoagulant collagen-and-thrombin–activated (COAT) platelet generation in platelet-rich plasma samples with low platelet counts
Optimized PRP recalcification prevents underestimation of procoagulant platelet potential in thrombocytopenic samples. This practical approach addresses a key gap identified by the International Society on Thrombosis and Haemostasis Scientific and Standardization Committee and helps laboratories to ensure reliable platelet function testing in PRP samples from thrombocytopenic patients.
Authors
- Lucas Veuthey (ORCID: https://orcid.org/0000-0003-3556-0430)
- Alessandro Aliotta (ORCID: https://orcid.org/0000-0002-9382-138X)
- Kamand Haeri
- Manuel Krüsi
- Lydia Hayenga
- Lorenzo Alberio
- Debora Bertaggia Calderara
Institutions
- University of Lausanne (CH)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.rpth.2026.103372
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Novartis Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Schweizerische Herzstiftung
- Novartis Stiftung für Medizinisch-Biologische Forschung