Epigenetic silencing and pharmacological inhibition of <i>EIF5A2</i> foster venetoclax sensitivity in acute myeloid leukaemia

We show how the loss of activity of the translation initiation factor EIF5A2-either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post-translational modification-induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.

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Publication Details

Journal
British Journal of Haematology
Published
2026-01-28
DOI
https://doi.org/10.1111/bjh.70339
Primary Topic
Polyamine Metabolism and Applications
Type
article
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article

Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

Manel Esteller, Laia Sancho‐Vila, Eva Crespo‐García, Aleix Noguera‐Castells et al.
British Journal of Haematology
Polyamine Metabolism and Applications
article

Epigenetic silencing and pharmacological inhibition of EIF5A2 foster venetoclax sensitivity in acute myeloid leukaemia

Manel Esteller, Laia Sancho‐Vila, Eva Crespo‐García, Aleix Noguera‐Castells, Laura Martinez‐Verbo, Carlos Quero‐Dotor
article en

Abstract

We show how the loss of activity of the translation initiation factor EIF5A2-either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post-translational modification-induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.

British Journal of Haematology
Universitat de Vic - Universitat Central de Catalunya (ES), Institució Catalana de Recerca i Estudis Avançats (ES), Josep Carreras Leukaemia Research Institute (ES), Centro de Investigación Biomédica en Red de Cáncer (ES), Universitat de Barcelona (ES), Epigenomics (Germany) (DE)
Openalex Percentile: Top 74%
Polyamine Metabolism and Applications
DOIOpen Access PDFOpenAlex
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Epigenetic silencing and pharmacological inhibition of <i>EIF5A2</i> foster venetoclax sensitivity in acute myeloid leukaemia — Manel Esteller, Laia Sancho‐Vila, et al. · British Journal of Haematology (2026) | TGRS Research Map | TGRS