Abstract WP032: Impact of stress-induced hyperglycemia on in-hospital medical complications in patients with acute stroke: From a large-scale nationwide longitudinal registry

Aims: This study aimed to explore the relationship of stress-induced hyperglycemia (SIH) and in-hospital medical complications in acute stroke patients. Methods: This study enrolled a total of 865,765 patients with acute stroke from the Chinese Stroke Center Alliance cohort. The stress hyperglycemia ratio (SHR) was defined as the ratio of fasting blood glucose to glycosylated hemoglobin. The primary outcome was in-hospital medical complications, including urinary tract infection (UTI), pneumonia, deep venous thrombosis (DVT), pulmonary embolism (PE), gastrointestinal bleeding (GIB), and pressure sores. Logistic regression analyses were performed to assess the association between SHR and in-hospital medical complications. Results: Total 104,873 (12.11%) patients with acute stroke experienced at least one in-hospital medical complication. The most frequently observed complications included pneumonia (9.84%), UTI (1.29%), and GIB (1.06%). Both univariate and multivariate logistic regression analyses showed that higher SHR was associated with a higher prevalence of pneumonia, UTI, GIB, and pressure sores (P for trend <0.01). After adjustment for potential confounders, DVT and PE risk declined with increasing SHR (P for trend < 0.05), which differed from other complications. In subgroup analysis, significant association between elevated levels of SHR and the occurrence of in-hospital complications was further confirmed (P<0.05). Conclusions: SIH was significantly associated with in-hospital medical complication in patients with acute stroke, particularly for pneumonia, UTI, GIB, and pressure sores.