Growth differentiation factor 15 as a biomarker of frailty: evidence from recent studies

GDF15 represents a promising biomarker for frailty, reflecting physical decline and risk of future frailty. Future research should address sex-specific effects, standardize assay protocols and frailty assessments, and explore the clinical utility of GDF15 to detect people at increased risk of decline in intrinsic capacity and frailty in a life course perspective.

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Publication Details

Journal
Current Opinion in Clinical Nutrition & Metabolic Care
Published
2026-01-29
DOI
https://doi.org/10.1097/mco.0000000000001213
Primary Topic
GDF15 and Related Biomarkers
Type
article
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article

Growth differentiation factor 15 as a biomarker of frailty: evidence from recent studies

Shuli Lian, Yves Rolland, Philipe de Souto Barreto
Current Opinion in Clinical Nutrition & Metabolic Care
GDF15 and Related Biomarkers
article

Growth differentiation factor 15 as a biomarker of frailty: evidence from recent studies

Shuli Lian, Yves Rolland, Philipe de Souto Barreto
article en

Abstract

GDF15 represents a promising biomarker for frailty, reflecting physical decline and risk of future frailty. Future research should address sex-specific effects, standardize assay protocols and frailty assessments, and explore the clinical utility of GDF15 to detect people at increased risk of decline in intrinsic capacity and frailty in a life course perspective.

Current Opinion in Clinical Nutrition & Metabolic Care
Université Toulouse III - Paul Sabatier (FR), Inserm (FR), Université Fédérale de Toulouse Midi-Pyrénées (FR), Centre Hospitalier Universitaire de Toulouse (FR), Cottage Health (US)
Openalex Percentile: Top 75%
GDF15 and Related Biomarkers
DOISourceOpenAlex
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Growth differentiation factor 15 as a biomarker of frailty: evidence from recent studies — Shuli Lian, Yves Rolland, et al. · Current Opinion in Clinical Nutrition & Metabolic Care (2026) | TGRS Research Map | TGRS