The role of batokines in metabolism and their therapeutic potential

Through its key role in the metabolism of lipids and carbohydrates, the mechanisms of BAT activation shed light on the complex mechanisms that interlink obesity with T2DM and other dysmetabolic conditions. Signaling biomolecules derived from BAT ('batokines') regulate the metabolic functioning of white adipose tissue and skeletal muscle, including glucose, lipid and protein metabolism, insulin sensitivity, and energy expenditure. Insights into batokine physiology will guide the next generation of therapies for obesity and its related dysmetabolic conditions.