Establishment and clinical application of a method for converting random quetiapine concentrations to steady-state trough concentrations

The conversion method, rigorously validated for both QTP and N-QTP with paired patient data, demonstrates robust component-specific and overall accuracy for clinical use. It provides a practical, eadily applicable lookup table to facilitate TDM interpretation when standard trough sampling is unfeasible, thereby supporting personalized quetiapine therapy for schizophrenia and bipolar disorder.