A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability
This review highlights the RS-CCD-CIN axis as a fragile and metastable architecture that supports cancer evolution, while also being susceptible to collapse. A deeper understanding of this interconnected framework may inform the development of therapeutic strategies and enhance the management of resistance.
Authors
- J Wang (ORCID: https://orcid.org/0009-0006-6620-2854)
- Di Ma (ORCID: https://orcid.org/0000-0002-7051-7393)
- Jian Wu (ORCID: https://orcid.org/0000-0001-7065-9917)
- Qianya Wei
- Yicong Chen
- Ling Yao
Institutions
- Gansu University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2026-01-28
- DOI
- https://doi.org/10.1080/07853890.2026.2620184
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00