DNA methylation-mediated silencing of MEOX1 promotes glycolysis and immune evasion in colorectal cancer cells through inhibition of GLP2R transcription
DNA hypermethylation blocked MEOX1-mediated GLP2R transcription, which activated glycolysis in CRC cells by inhibiting Hippo signaling, leading to CRC growth, metastasis, and immune evasion.
Authors
- Fen Xue (ORCID: https://orcid.org/0009-0002-3361-1206)
- Xiao Ni (ORCID: https://orcid.org/0000-0002-0154-446X)
- Dingkong Liang (ORCID: https://orcid.org/0009-0009-4628-3556)
- Jinkun Xie
- Jingzhe Zhang
- Honggang Gu
- Jiyong Yang
Institutions
- Fudan University Shanghai Cancer Center (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s13578-026-01534-x
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00