Akkermansia muciniphila Ameliorates Chronic Sleep Deprivation-Induced Glucose Intolerance and Inflammatory Cytokine Activation
<i>A. muciniphila</i> supplementation effectively ameliorated CSD-induced glucose intolerance, reduced the serum levels of LPS and proinflammatory cytokines (IL-6, TNF-α, and IL-1β), and restored intestinal barrier integrity by upregulating MUC2 and ZO-1 expression in colon tissues.
Authors
- Lei Guo (ORCID: https://orcid.org/0000-0003-2055-7618)
- Mo Li (ORCID: https://orcid.org/0000-0003-0827-8907)
- Yanhua Ma
- Zhenxing Wang (ORCID: https://orcid.org/0009-0009-9871-0425)
- Qi Pan
- Xun Jiang
- Mingqun Deng
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking Union Medical College Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-01-21
- DOI
- https://doi.org/10.31083/fbl45680
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00