Abstract TP183: Dual burden of Prostate cancer and Stroke in US Men Aged 55 and Older: Insights from Multiple Cause of Death Data

Background: Prostate cancer and stroke remain the leading causes of death among older men in the US. Although examined separately, little has been examined regarding their joint mortality rates. Demographic and geographic differences must be understood for developing targeted prevention interventions and improving outcomes in high-risk populations. Methods: The data regarding mortality was extracted from the CDC Multiple Cause of Death database for U.S. men aged 55 years or older from 2018 to 2023. Information regarding death was identified by using ICD-10 codes when both conditions appeared on the same death certificate. We utilized the Joinpoint Regression Program for estimating age-adjusted mortality rates (AAMRs) per million and annual percent changes (APCs) and stratified them by state, age group, race/ethnicity, and U.S. Census area. Results: The overall mortality rate increased significantly between 2018 and 2023, with the AAMR rising from 61.78 to 80.97 and an average APC (AAPC) of 5.81%. By age group, the overall mortality rate of men aged 55–74 was lower at 17.47 but increased more sharply (AAPC 6.99%) as compared to men aged >75, who had a substantially higher overall mortality rate at 218.10, with slower growth (AAPC 4.24%). By race, the highest mortality rate was observed in non-Hispanic (NH) Black men, with an overall AAMR of 159.97 (AAPC: 7.07%). Although NH Asian men had the lowest mortality rate at 30.98, they experienced the fastest rise (AAPC: 7.70%). NH White men's AAMR was 70.60 (AAPC: 5.73%), whereas Hispanic men's was 53.28 (AAPC: 5.21%). Regionally, the West had the greatest AAMR at 79.92 (AAPC 6.04%), whereas the South had the most rapid increase in mortality (AAPC: 7.50%) and an overall AAMR of 77.17. The Midwest and Northeast had AAMRs of 73.90 (AAPC: 2.90) and 61.08 (AAPC: 5.01), respectively. At the state level, Colorado, Mississippi, Oregon, and Minnesota were among those with the highest mortality rates, whereas Kansas, Massachusetts, Nevada, Illinois, Connecticut, and Arizona had the lowest AAMRs, all below 10 per million. Conclusion: Rising mortality due to combined prostate cancer and stroke burden is being noticed among men in the U.S., and it has the most profound effect within age 75 or above, NH Black men, and southern areas. These results emphasize growing disparities and the need for targeted, data-driven public health strategies.