Microbiota-driven therapeutic efficacy of Hyperoside in ulcerative colitis and associated anxiety
Our findings demonstrate that HYP effectively alleviates DSS-induced colitis and comorbid anxiety-like behaviors. Its efficacy is dependent on the gut microbiota and is associated with the restoration of microbial homeostasis, enhancement of arginine metabolism, and modulation of the MAPK/PI3K-Akt/NF-κB signaling pathways. HYP represents a promising microbiota-targeting therapeutic candidate for UC and its neuropsychiatric comorbidities.
Authors
- Li Yin (ORCID: https://orcid.org/0000-0002-7448-0284)
- Yanbin Li (ORCID: https://orcid.org/0000-0003-1695-6309)
- Lin Xu (ORCID: https://orcid.org/0000-0003-2487-6528)
- Yunan Shan
- Zhilin He
- Wei Chen
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Hubei University of Chinese Medicine (CN)
- Shanghai Sixth People's Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fcimb.2026.1734356
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China