Thromboembolic Events During Perioperative Therapy for Resectable and Borderline Resectable Pancreatic Cancer in the PREOPANC-2 Trial
VTE occurred in 9% of patients with (borderline) resectable PDAC undergoing (neo)adjuvant treatment in the year after random assignment and was associated with decreased OS. These results underscore the need for standardized reporting of thromboembolic events in clinical trials and future studies assessing the potential benefits of thromboprophylaxis during neoadjuvant therapy.
Authors
- Flip M. Kruyt
- Roeland De Wilde
- S. Bouwense
- K. Hermans
- Suzan Vrijaldenhoven
- Judith de Vos‐Geelen (ORCID: https://orcid.org/0000-0003-2578-1766)
- C. Yung Nio
- Gijs A. Patijn
- Saskia A. C. Luelmo (ORCID: https://orcid.org/0000-0002-9298-2878)
- Leonie J. Mekenkamp
- Bo T M Strijbos (ORCID: https://orcid.org/0009-0001-6824-3354)
- Mark R. Roest
- G. Patijn (ORCID: https://orcid.org/0000-0001-8113-4171)
- Barbara M. Zonderhuis
- Esther N. Dekker (ORCID: https://orcid.org/0000-0002-3040-6736)
- Anouk J. de Wilde (ORCID: https://orcid.org/0000-0002-2389-1171)
- M. B. van der Kolk
- Mirte Mayke Streppel
- Joost JME Nuyttens
- Peter-Paul L.O Coene
- Vincent B. Nieuwenhuijs (ORCID: https://orcid.org/0000-0001-9311-8208)
- M. Stommel
- O. J. L. Loosveld
- Aniek E. van Diepen (ORCID: https://orcid.org/0009-0007-0192-5354)
- Nick van Es
- Eva Versteijne
- Marjolein Y.V. Homs
- Jacob L. van Dam
- Marlies L. van Bekkum
- Eva M.M. Verkolf
- Bas Groot Koerkamp
- Bas de Laat
- Liselot Valkenburg-van Iersel (ORCID: https://orcid.org/0000-0003-2925-9908)
- Ignace H.J.T. de Hingh
- Hugo ten Cate
- T.F. Stoop
- R.T. Theijse
- D. ten Oever
- Lieke Brouwer-Hol
- J. Sven D. Mieog
- Geertjan van Tienhoven
- Geert A. Cirkel
- Daphne H.M. Droogh
- Brigitte C.M. Haberkorn
- Nynke Michiels
- Jan Willem B. de Groot
- Ruth A.L. Willems
- Marc G. Besselink
- Koop P. Bosscha
- Fennie Wit
- Quisette P. Janssen
- Geert Kazemier
- for the Dutch Pancreatic Cancer Group
- Olivier R. Busch
- Anna M.E. Bruynzeel
- Olaf J.L. Loosveld
- Johanna W. Wilmink
- Misha D.P. Luyer
- Hendrik Bos
- Laurens V. Beerepoot
- Ingmar F. Rompen
- Casper H.J. van Eijck
- Erwin van der Harst
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Catharina Ziekenhuis (NL)
- Medisch Spectrum Twente (NL)
- Erasmus MC (NL)
- Medisch Centrum Leeuwarden (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- OLVG (NL)
- Amsterdam Neuroscience (NL)
- Maasstad Ziekenhuis (NL)
- Synapse (Netherlands) (NL)
- Isala (NL)
- Erasmus MC Cancer Institute (NL)
- Amsterdam University Medical Centers (NL)
- Jeroen Bosch Ziekenhuis (NL)
- Maastro Clinic (NL)
- Cancer Center Amsterdam (NL)
- University of Amsterdam (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1200/jco-25-01935
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00