Brain-Resident MAIT Cells Infiltrate GL261 Tumors, and Activated MAIT Cell Signatures Are Associated With Improved Outcomes in Glioma
Overall, this study supports a protective role for a population of brain-resident MAIT cells in glioma and highlights their potential involvement in immune surveillance of the CNS. Our findings also lay a foundation to explore the therapeutic modulation of MAIT cells in the brain.
Authors
- Alexander D. Barrow (ORCID: https://orcid.org/0000-0001-5833-0537)
- Eleanor M. Eddy
- Alexandra Jane Corbett (ORCID: https://orcid.org/0000-0003-1618-4337)
- Adam G. Nelson (ORCID: https://orcid.org/0000-0002-5897-791X)
- James McCluskey (ORCID: https://orcid.org/0000-0002-8597-815X)
- Riccardo Dolcetti (ORCID: https://orcid.org/0000-0003-1625-9853)
- Roberta Mazzieri (ORCID: https://orcid.org/0000-0002-5172-0927)
- Jeremy P. Le (ORCID: https://orcid.org/0009-0009-4383-0227)
- Zhenjun Chen (ORCID: https://orcid.org/0000-0003-1205-683X)
- Michael N. T. Souter (ORCID: https://orcid.org/0000-0002-1459-7923)
- Timothy Patton (ORCID: https://orcid.org/0000-0002-9642-7003)
- Davide Moi (ORCID: https://orcid.org/0000-0002-1198-5146)
- Huimeng Wang (ORCID: https://orcid.org/0000-0003-0226-3982)
- Shihan Li (ORCID: https://orcid.org/0000-0003-3207-7064)
- Phoebe M. Dewar
- Md Abdullah Al Kamran Khan
Institutions
- The University of Melbourne (AU)
- Peter MacCallum Cancer Centre (AU)
- Hudson Institute of Medical Research (AU)
- Peter Doherty Institute (AU)
Publication Details
- Journal
- Neurology Neuroimmunology & Neuroinflammation
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1212/nxi.0000000000200546
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00