Optimization of M1 macrophage targeting using a glucosylated albumin nanoplatform for ROS scavenging and mitochondrial rescue in acute kidney injury
Glc<sup>6</sup>-AD<sup>11</sup>-Alb acts through complementary mechanisms of macrophage-targeted immune modulation and mitochondrial protection, thereby disrupting the vicious cycle of inflammation and oxidative stress in AKI. This nanoplatform represents a clinically translatable therapeutic strategy with potential to improve outcomes in patients with ischemic kidney injury.
Authors
- Dong Ki Kim
- Seong Min Lee (ORCID: https://orcid.org/0000-0001-5017-5456)
- Yun‐Sang Lee (ORCID: https://orcid.org/0000-0003-1640-2090)
- Kyung Don Yoo (ORCID: https://orcid.org/0000-0001-6545-6517)
- S. Yang
- Young Chan Ann
- Ji Yong Park
- Joo Yeon Oh
- Jung Nam An
- Yon Su Kim
- Eunjin Bae
- Yong Chul Kim
- Ran Ji Yoo
- Hyeri Chae
- Sung Hyun Hong
Institutions
- Seoul National University (KR)
- Cancer Research Institute (US)
- Gyeongsang National University (KR)
- Seoul National University Hospital (KR)
- RBio (South Korea) (KR)
- National University College (PR)
- Ulsan University Hospital (KR)
- Hallym University Sacred Heart Hospital (KR)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s12951-026-04061-6
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00