Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline

These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes.

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Publication Details

Journal
Alzheimer s Research & Therapy
Published
2026-01-29
DOI
https://doi.org/10.1186/s13195-026-01964-2
Primary Topic
Cerebrospinal fluid and hydrocephalus
Type
article
Field-Weighted Citation Impact
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article

Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline

K. Blennow, Eung Yeop Kim, Jun Pyo Kim, D. L. Na et al.
Alzheimer s Research & Therapy
Cerebrospinal fluid and hydrocephalus
article

Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline

K. Blennow, Eung Yeop Kim, Jun Pyo Kim, D. L. Na, Heejin Yoo, Fernando González-Ortiz, Theresa A. Day, H. Kim, Seongmi Kim, Beomseok Sohn, H. J. Jang, Henrick Zetterberg, Eun Hye Lee, Sung Tae Kim, Young Ju Kim, Daeun Shin, Sang-Young Kim, Jihwan Yun, Sang Won Seo, Sung Hoon Kang, Marco Duering, Seong-Beom Koh, Nicholas J. Ashton
article en

Abstract

These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes.

Alzheimer s Research & TherapyVol. 18(1)
University of Science and Technology of China (CN), Philips (Finland) (FI), University of Wisconsin–Madison (US), Eli Lilly (United States) (US), King's College London (GB), University of Basel (CH), South London and Maudsley NHS Foundation Trust (GB), Korea University Medical Center (KR), Stavanger University Hospital (NO), Hong Kong Science and Technology Parks Corporation (HK), Sahlgrenska University Hospital (SE), Samsung Medical Center (KR), Stroke Association (GB), Kyung Hee University (KR), Sorbonne Université (FR), Pitié-Salpêtrière Hospital (FR), UK Dementia Research Institute (GB), National Hospital for Neurology and Neurosurgery (GB), Korea University (JP), University College London (GB), Ludwig-Maximilians-Universität München (DE), Sungkyunkwan University (KR), University of Gothenburg (SE)
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Openalex Percentile: Top 75%
Cerebrospinal fluid and hydrocephalus
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