Glymphatic dysfunction links vascular pathology to Alzheimer’s biomarkers and cognitive decline
These findings highlight glymphatic dysfunction as a key mechanism linking vascular pathology with tau, inflammation and neurodegeneration, independent of Aβ uptakes.
Authors
- K. Blennow
- Eung Yeop Kim (ORCID: https://orcid.org/0000-0002-9579-4098)
- Jun Pyo Kim (ORCID: https://orcid.org/0000-0003-4376-3107)
- D. L. Na
- Heejin Yoo (ORCID: https://orcid.org/0000-0002-9630-8207)
- Fernando González-Ortiz
- Theresa A. Day
- H. Kim
- Seongmi Kim (ORCID: https://orcid.org/0009-0004-3144-9908)
- Beomseok Sohn (ORCID: https://orcid.org/0000-0002-6765-8056)
- H. J. Jang
- Henrick Zetterberg
- Eun Hye Lee (ORCID: https://orcid.org/0000-0002-4206-6214)
- Sung Tae Kim (ORCID: https://orcid.org/0000-0001-6427-9635)
- Young Ju Kim (ORCID: https://orcid.org/0000-0003-2927-6724)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Sang-Young Kim (ORCID: https://orcid.org/0000-0001-9220-1296)
- Jihwan Yun (ORCID: https://orcid.org/0009-0000-4084-7327)
- Sang Won Seo
- Sung Hoon Kang
- Marco Duering
- Seong-Beom Koh
- Nicholas J. Ashton
Institutions
- University of Science and Technology of China (CN)
- Philips (Finland) (FI)
- University of Wisconsin–Madison (US)
- Eli Lilly (United States) (US)
- King's College London (GB)
- University of Basel (CH)
- South London and Maudsley NHS Foundation Trust (GB)
- Korea University Medical Center (KR)
- Stavanger University Hospital (NO)
- Hong Kong Science and Technology Parks Corporation (HK)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Stroke Association (GB)
- Kyung Hee University (KR)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Korea University (JP)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s13195-026-01964-2
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00