White Matter Hyperintensity Burden and Decline in Driving Performance Among Older Adults
In this cohort study of older drivers, higher WMH burden, especially in posterior regions, was associated with progressive driving self-regulation and increased errors in those developing cognitive impairment. Antihypertensive use attenuated WMH-associated unsafe driving. Posterior WMH may represent a biomarker for identifying older drivers at risk and may inform mobility-preserving interventions in aging populations.
Authors
- Yu Zhu (ORCID: https://orcid.org/0000-0002-1998-0294)
- JF Trani
- Matthew Blake
- Carson Woodfin
- Semere Bekena (ORCID: https://orcid.org/0009-0008-6514-0502)
- Madhur Parihar
- Jin-Moo Lee
- Chia-Ling Phuah
- Kaylin Taylor
- Ganesh M. Babulal
- David B. Carr
- Yasheng Chen
- Driving Real-World In-Vehicle Evaluation System (DRIVES) Project
- Byron Xu
- Ann M. Johnson
- Chen Chen
- Maeve Intagliata
- Ramkrishna K. Singh
Institutions
- Barrow Neurological Institute (US)
- Washington University in St. Louis (US)
- University of Johannesburg (ZA)
- Diagnostics for the Real World (United Kingdom) (GB)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.54501
- Primary Topic
- Older Adults Driving Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00