Does the Benefit of Thrombectomy in Large Strokes Depend on Perfusion–Diffusion Mismatch? A Large Stroke Therapy Evaluation Trial Post Hoc Analysis

Our study found no evidence of heterogeneity of treatment effect with respect to benefit or safety in patients with unrestricted infarct size at baseline treated with MT by presence of perfusion-diffusion mismatch. An individual participant-data meta-analysis of RCT is needed for definitive conclusions.

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Publication Details

Journal
Journal of Stroke
Published
2026-01-29
DOI
https://doi.org/10.5853/jos.2025.01200
Primary Topic
Acute Ischemic Stroke Management
Type
article
Field-Weighted Citation Impact
0.00

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article

Does the Benefit of Thrombectomy in Large Strokes Depend on Perfusion–Diffusion Mismatch? A Large Stroke Therapy Evaluation Trial Post Hoc Analysis

Mariam Annan, M Piotin, Julien Labreuche, Eker Omer et al.
Journal of Stroke
Acute Ischemic Stroke Management
article

Does the Benefit of Thrombectomy in Large Strokes Depend on Perfusion–Diffusion Mismatch? A Large Stroke Therapy Evaluation Trial Post Hoc Analysis

Mariam Annan, M Piotin, Julien Labreuche, Eker Omer, Emmanuelle Le Bars, Igor Sibon, Michaël Obadia, Adrien ter Schiphorst, Federico Di Maria, Tae-Hee Cho, Nasreddine Nouri, Bertrand Lapergue, Hilde Henon, Sébastien Richard, David S. Liebeskind, Christophe Cognard, Tudor G. Jovin, Caroline Arquizan, Liesjet van Dokkum, Grégoire Boulouis, Benoit Guillon, Benjamin Gory, Olivier Naggara, Jean-François Albucher, Romain Bourcier, Vincent Costalat, Emmanuel Chabert, Guillaume Turc, Mònica Millán, Anna Ferrier
article en

Abstract

Our study found no evidence of heterogeneity of treatment effect with respect to benefit or safety in patients with unrestricted infarct size at baseline treated with MT by presence of perfusion-diffusion mismatch. An individual participant-data meta-analysis of RCT is needed for definitive conclusions.

Journal of StrokeVol. 28(1)
Centre National de la Recherche Scientifique (FR), Inserm (FR), University of California, Los Angeles (US), Université Fédérale de Toulouse Midi-Pyrénées (FR), Université de Versailles Saint-Quentin-en-Yvelines (FR), Université de Montpellier (FR), Université Paris Cité (FR), Cooper University Hospital (US), Centre Hospitalier Universitaire de Lille (FR), Cooper Medical School of Rowan University (US), Centre Hospitalier Universitaire de Tours (FR), Hôpital Bretonneau (FR), Hospices Civils de Lyon (FR), Centre d’Investigation Clinique Innovation Technologique de Nancy (FR), Hôpital Pierre Wertheimer (FR), Hôpital Gui de Chauliac (FR), Hôpital Pellegrin (FR), Imagerie Adaptative Diagnostique et Interventionnelle (FR), Fondation Ophtalmologique Adolphe de Rothschild (FR), Centre Hospitalier Sainte-Anne (FR), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), Institut de Psychiatrie et Neurosciences de Paris (FR), Institut du Thorax (FR), FHU Neurovasc (FR), Centre d'Investigation Clinique Pierre Drouin (FR), Hospital Universitari Germans Trias i Pujol (ES), Hôpital Paule de Viguier (FR), Institut de Génomique Fonctionnelle (FR), Hôpital Foch (FR), Hôpital Laennec (FR), Université de Lorraine (FR), Nantes Université (FR)
Amgen, Bristol-Myers Squibb, Pfizer, Sanofi, Stryker, Bracco Imaging
Good health and well-being
Openalex Percentile: Top 74%
Acute Ischemic Stroke Management
DOIOpen Access PDFOpenAlex
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