Do the redefined EUCAST susceptibility categories warrant adjustment of paediatric antibiotic dosages? Pragmatic physiologically based pharmacokinetic modelling of four commonly used agents
In contrast to adults, there is no need to increase the currently recommended paediatric dosages for the tested antibiotics. At the same time, further simulations showed that the PTA varies by drug-micro-organism combination and age, providing a potential opportunity to tailor doses to individual patients.
Authors
- Joannes F.M. Jacobs (ORCID: https://orcid.org/0000-0002-6208-6386)
- Roger J. M. Brüggemann (ORCID: https://orcid.org/0000-0002-7618-725X)
- Saskia N. de Wildt (ORCID: https://orcid.org/0000-0002-0502-0647)
- Clementien L. Vermont (ORCID: https://orcid.org/0000-0002-2219-856X)
- Rick Greupink
- T F W Wolfs
- Shannon L van der Zeeuw
- Marika A de Hoop-Sommen
- Joyce E M van der Heijden
- Yvette Oosterlaan
- Chantal M Staring
- Tjitske M van der Zanden
- Jan-Tom van der Bruggen
- Marjolijn S W Quaak
- Jolien J M Freriksen
Institutions
- Radboud University Nijmegen (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Royal Dutch Pharmacists Association (NL)
- Radboud Institute for Molecular Life Sciences (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Westfriesgasthuis (NL)
- Wilhelmina Children's Hospital (NL)
- Erasmus University Rotterdam (NL)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1093/jac/dkaf463
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bill and Melinda Gates Foundation