Corrigendum to: Elucidating the Functional Role of Predicted miRNAs inPost-Transcriptional Gene Regulation Along with Symbiosis in Medicagotruncatula

<p>An error was made in the research paper titled "Elucidating the Functional Role of Predicted miRNAs in Post- Transcriptional Gene Regulation Along with Symbiosis in Medicago truncatula." There is a problem with the number as it does not match the main manuscript with the abstract, which was published in Current Bioinformatics, 2020, Vol. 15, No. 2 [1]. </p> <p> Details of the error and a correction are provided here. </p> <p> Original: </p> <p> Abstract: Background: microRNAs are small non-coding RNAs which inhibit translational and post-transcriptional processes whereas long non-coding RNAs are found to regulate both transcriptional and post-transcriptional gene expression. Medicago truncatula is a well-known model plant for studying legume biology and is also used as a forage crop. In spite of its importance in nitrogen fixation and soil fertility improvement, little information is available about Medicago noncoding RNAs that play important role in symbiosis. </p> <p> Objective: In this study we have tried to understand the role of Medicago ncRNAs in symbiosis and regulation of transcription factors. </p> <p> Methods: We have identified novel miRNAs by computational methods considering various parameters like length, MFEI, AU content, SSR signatures and tried to establish an interaction model with their targets obtained through psRNATarget server. </p> <p> Results: 149 novel miRNAs are predicted along with their 770 target proteins. We have also shown that 51 of these novel miRNAs are targeting 282 lncRNAs. </p> <p> Conclusion: In this study role of Medicago miRNAs in the regulation of various transcription factors are elucidated. Knowledge gained from this study will have a positive impact on the nitrogen fixing ability of this important model plant, which in turn will improve the soil fertility. </p> <p> Corrected: </p> <p> Abstract: Background: Non-coding RNAs (ncRNAs) are important regulators of gene expression. MicroRNAs (miRNAs) are small ncRNAs, which inhibit translational and post-transcriptional processes, whereas long ncRNAs regulate both transcriptional and post-transcriptional gene expression. Medicago truncatula is a well-known model plant for studying legume biology. Despite its importance in nitrogen fixation, little information is available about Medicago ncRNAs that play an important role in symbiosis. </p> <p> Objective: This study aims to predict the miRNAs and their targets from the genome of M. truncatula and elucidate their roles in symbiosis and transcriptional regulation. </p> <p> Methods: We have developed a computational method to identify miRNAs in M. truncatula. In addition, we have also predicted the targets of these miRNAs involved in various biological processes and established an interaction model for symbiosis. </p> <p> Results: We have predicted 186 miRNAs, of which 165 are novel. Additionally, 770 proteins targeted by these miRNAs are also predicted. We show that 51 of these novel miRNAs target 282 lncRNAs. The symbiosis-related gene regulation is explored through analyzing the interactions between predicted miRNAs and their nodulin target proteins. </p> <p> Conclusion: Knowledge gained from this study will enhance our understanding of the nitrogen-fixing ability of this important model plant, which in turn will improve soil fertility. </p> <p> We regret the error and apologize to readers. </p> <p> The original article can be found online at https://www.eurekaselect.com/article/101155</p>