Association of allostatic load with frailty trajectories and the mediating role of depressive symptoms
Socioeconomic factors influenced frailty onset but not its progression, whereas depressive symptoms mediated approximately 17% of the effect of ALS on frailty development over time. These findings highlight the importance of exploring the effect of interventions for depression on frailty progression.
Authors
- Robab Breyer‐Kohansal (ORCID: https://orcid.org/0000-0001-5850-5923)
- Daisy J.A. Janssen (ORCID: https://orcid.org/0000-0002-1827-9869)
- Agnes Pirker-Kees (ORCID: https://orcid.org/0000-0002-0956-4246)
- Bart Spaetgens (ORCID: https://orcid.org/0000-0003-3062-2612)
- Mohammad Azizzadeh (ORCID: https://orcid.org/0000-0001-9192-5022)
- Emiel F.M. WOUTERS
- Marie-Kathrin Breyer
Institutions
- Sigmund Freud Privatuniversität Wien (AT)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Klinik Hietzing (AT)
- Ludwig Boltzmann Institute for Lung Vascular Research (AT)
- Department of Health (TW)
- Department of Health Services (NP)
- Karl Landsteiner Society (AT)
Publication Details
- Journal
- The Journal of Frailty & Aging
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.tjfa.2026.100132
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00