Cyanidin-3-glucoside confers neuroprotection in ischemic stroke by targeting NOX4-mediated oxidative stress: A network pharmacology and experimental validation study
C-3-G mitigates ischemia-reperfusion-induced oxidative stress and tissue injury by targeting Nox4 and modulating the Nrf2-Keap1-HO-1 antioxidant axis, supporting its potential as an adjunct therapy in the acute phase of ischemic stroke.
Authors
- Lijuan Gu (ORCID: https://orcid.org/0000-0003-1928-8772)
- Xiaoxing Xiong (ORCID: https://orcid.org/0000-0001-6983-8547)
- Jiehua Zhang
- Yingze Ye
- Jin Wang
- Xiaoting Li
- Yikun Gao
- Liang Wei
Institutions
- Wuhan University (CN)
- Maternal and Child Health Hospital of Sichuan Province (CN)
- Renmin Hospital of Wuhan University (CN)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.biopha.2026.119072
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00