The prognostic significance of JAML and its role in remodeling the immune microenvironment via the cGAS-STING pathway in endometrial cancer
These findings suggest that JAML deficiency may suppress cyclic GMP-AMP synthase (cGAS)-STING pathway activation, potentially contributing to M1/M2 macrophage polarization imbalance and facilitating EC progression. Clinically, JAML expression shows promise as a potential biomarker for prognostic stratification and treatment response prediction (chemotherapy/immunotherapy), providing insights for developing precision immunochemotherapy strategies in EC.
Authors
- Chenfan Tian (ORCID: https://orcid.org/0009-0009-3301-4322)
- Chunxia Gong
- Jingwei Yu (ORCID: https://orcid.org/0000-0002-7587-754X)
- Yuan Tu (ORCID: https://orcid.org/0000-0002-9800-4637)
- Hong Yu (ORCID: https://orcid.org/0000-0002-4425-3697)
- Yuanyang Yao
- Peng Jiang
- Xiuling Shi
Institutions
- Peking University (CN)
- Peking University People's Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fimmu.2026.1738596
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00