Turmeric-Derived Exosome-Like Nanoparticles Inhibit Non-Small Cell Lung Cancer via Epigenetic Regulation

This study reveals a novel epigenetic mechanism wherein TELNs suppress NSCLC by activating hMOF/H4K16ac. Curcumin within TELNs increases hMOF levels, thus positioning TELNs as a potential nanotherapeutics with the capacity for epigenetic modulation. Our findings underscore the potential of TELNs in NSCLC treatment and highlight hMOF as a therapeutic target.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2026-01-08
DOI
https://doi.org/10.31083/fbl47950
Primary Topic
Curcumin's Biomedical Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Turmeric-Derived Exosome-Like Nanoparticles Inhibit Non-Small Cell Lung Cancer via Epigenetic Regulation

Wenyu Sun, Da Liu
Frontiers in Bioscience-Landmark
Curcumin's Biomedical Applications
article

Turmeric-Derived Exosome-Like Nanoparticles Inhibit Non-Small Cell Lung Cancer via Epigenetic Regulation

Wenyu Sun, Da Liu
article en

Abstract

This study reveals a novel epigenetic mechanism wherein TELNs suppress NSCLC by activating hMOF/H4K16ac. Curcumin within TELNs increases hMOF levels, thus positioning TELNs as a potential nanotherapeutics with the capacity for epigenetic modulation. Our findings underscore the potential of TELNs in NSCLC treatment and highlight hMOF as a therapeutic target.

Frontiers in Bioscience-LandmarkVol. 31(1)
Tianjin Medical University Cancer Institute and Hospital (CN), Jilin Province Tumor Hospital (CN), Changchun University of Chinese Medicine (CN)
People's Government of Jilin Province
Good health and well-being
Openalex Percentile: Top 71%
Curcumin's Biomedical Applications
DOIOpen Access PDFOpenAlex
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Turmeric-Derived Exosome-Like Nanoparticles Inhibit Non-Small Cell Lung Cancer via Epigenetic Regulation — Wenyu Sun, Da Liu · Frontiers in Bioscience-Landmark (2026) | TGRS Research Map | TGRS