Comparing Different <scp> <i>As‐Treated</i> </scp> Approaches: A Methodological Study Using Real‐World Data on Psoriasis Treatments

The number of events within the exposure group varied by approaches, influencing the HR estimates. The multi-switch approach effectively captured treatment switching and reduced statistical uncertainty, supporting clearer safety conclusions. Tracking each treatment period with gaps reflects real-world practice but may lower statistical power and should be carefully considered in analyses.