TAFA4 Mitigates Intervertebral Disc Degeneration by Modulating Macrophage Polarization and Inhibiting ROS-NLRP3 Inflammasome Activation
TAFA4 acts as a neuron-derived mediator of neuroimmune crosstalk in IVDD that modulates macrophage polarization and oxidative stress, thereby delaying disc degeneration. This neuron-immune axis represents a potential therapeutic target.
Authors
- Zhili Ding
- Jingbo Ma
- Zhaokun Lu
- Yan Zhang
- Qiang Jiang
- Yu Ding
- Jie Huang
- Guangnan Yang
Institutions
- Anhui Medical University (CN)
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Peking University People's Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Neurospine
- Published
- 2026-01-30
- DOI
- https://doi.org/10.14245/ns.2551048.524
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China