Appropriate Medical Therapy Primarily Modifies Type 2 and Severity Biomarkers in Chronic Rhinosinusitis
AMT for CRS is associated with reduction in index biomarkers across inflammatory severity and T2 endotype with minimal effects on T1/3 inflammation. T2-driven inflammation appears to be the most AMT-responsive axis found in this study, aligning with measurable improvements in endoscopic, patient reported, and nasal airflow outcomes.
Authors
- Eli Stein (ORCID: https://orcid.org/0000-0002-5569-7795)
- Saied Ghadersohi (ORCID: https://orcid.org/0000-0002-9742-5333)
- Brooke N. Gleason (ORCID: https://orcid.org/0009-0008-5614-4990)
- Robert C. Kern
- Kevin C. Welch
- David B. Conley
- Asher C. Park
- Bruce K. Tan
- Stephanie Shintani‐Smith
Institutions
- Northwestern University (US)
- Columbia University (US)
Publication Details
- Journal
- International Forum of Allergy & Rhinology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1002/alr.70105
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 53.14
Funders
- National Institutes of Health