FUBP3-Mediated Recruitment of STAT3 Complex Formation to Activate EMT Factor Twist1 and Promote Lung Cancer Metastasis
This study reveals the critical role of FUBP3 in lung cancer metastasis and identifies a new regulatory axis involving FUBP3-STAT3-Twist1. FUBP3 interacts with STAT3, enhancing STAT3-dependent Twist1 expression, which promotes EMT and metastasis. FUBP3 functions as a prognostic biomarker, and STAT3 inhibitors present therapeutic strategies for lung cancer, offering novel insights for precision treatment.
Authors
- Liang Zhang (ORCID: https://orcid.org/0000-0003-3543-9382)
- Wenying Wang
- Ping Wang
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Liaocheng People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Bioscience-Landmark
- Published
- 2026-01-20
- DOI
- https://doi.org/10.31083/fbl47541
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00