Methylation-specific, universal, and highly sensitive identification of ctDNA in prostate cancer by multiplex droplet digital PCR
This work demonstrates that the mm-ddPCR assay offers a simple, fast, cost-effective, sensitive, and universal tool for the detection of ctDNA biomarkers in plasma from mCRPC patients. Further studies are required to explore its potential for PCa risk stratification and treatment guidance.
Authors
- Søren Kahns
- Ahmed Hussein Zedan (ORCID: https://orcid.org/0000-0002-8895-6394)
- Stine V Eriksen (ORCID: https://orcid.org/0009-0008-2123-083X)
- Mads Malik Aagaard
- Palle J. S. Osther
- Rikke F. Andersen
- Luisa M. D. Canto
- Sanne Kjær-Frifeldt
- Torben F. Hansen
- Jonna S. Madsen
- Christine V. Madsen
Institutions
- University of Southern Denmark (DK)
- Vejle Sygehus (DK)
- Region of Southern Denmark (DK)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1371/journal.pone.0340786
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00