Exploring SPARC over Other Exerkines/Myokines: A Strategic Approach Towards Novel Exercise-Mimicking Therapies
Identifying novel therapeutic targets for diseases and health conditions represents an important step towards new therapies. Functional genomics and proteomics represent promising tools in identifying such pharmacological targets. Within this context, numerous biomolecules have been characterized as exercise-induced (exerkines) in muscles (myokines). In this article, we present illustrative examples of why secreted protein acidic and rich in cysteine (SPARC) would be a "leading candidate" myokine/exerkine for exploring exercise-induced genes/proteins to develop therapies, clarify mechanisms, and improve various aspects of biomedical research, including population health.
Authors
- Jonny St‐Amand (ORCID: https://orcid.org/0000-0002-2595-6127)
- Roseane de Fátima Guimarães (ORCID: https://orcid.org/0000-0001-8151-7914)
- Abdelaziz Ghanemi (ORCID: https://orcid.org/0000-0001-9676-1119)
- Mayumi Yoshioka (ORCID: https://orcid.org/0000-0003-3519-9024)
Institutions
- University of Victoria (CA)
- Innovation and Economic Development Trois Rivières (CA)
- Université Laval (CA)
- Université du Québec à Trois-Rivières (CA)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3390/biomedicines14020302
- Primary Topic
- Bone and Dental Protein Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stem Cell Network
- Simon Fraser University
- Mitacs
- Natural Sciences and Engineering Research Council of Canada