Optimising response assessment to neoadjuvant therapy in rectal cancer to reduce the incidence of ypT0N0 resection

The clinical assessment of response to neo-adjuvant therapy in patients with rectal cancer is an area that requires improvement due to overtreatment. ypT0N0 patients often have discordant investigations. Management decisions based on the concordance of investigations may reduce the number of ypT0N0 resections.

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Publication Details

Journal
International Journal of Colorectal Disease
Published
2026-01-29
DOI
https://doi.org/10.1007/s00384-025-05034-1
Primary Topic
Colorectal Cancer Surgical Treatments
Type
article
Field-Weighted Citation Impact
0.00
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article

Optimising response assessment to neoadjuvant therapy in rectal cancer to reduce the incidence of ypT0N0 resection

Tracey Skinner, Andrew Kneebone, Keshani De Silva, George Hruby et al.
International Journal of Colorectal Disease
Colorectal Cancer Surgical Treatments
article

Optimising response assessment to neoadjuvant therapy in rectal cancer to reduce the incidence of ypT0N0 resection

Tracey Skinner, Andrew Kneebone, Keshani De Silva, George Hruby, Kah Hoong Chang, Justin Evans, Nick Pavlakis, Yasser Salama, Jonathan Hew, Katerina Mastrocostas
article en

Abstract

The clinical assessment of response to neo-adjuvant therapy in patients with rectal cancer is an area that requires improvement due to overtreatment. ypT0N0 patients often have discordant investigations. Management decisions based on the concordance of investigations may reduce the number of ypT0N0 resections.

International Journal of Colorectal DiseaseVol. 41(1)
The University of Sydney (AU), Royal North Shore Hospital (AU)
Openalex Percentile: Top 74%
Colorectal Cancer Surgical Treatments
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