Oncogenic Role of KIF18B Across Human Cancers: A Pan-Cancer Bioinformatic Analysis and Experimental Validation in Lung Adenocarcinoma

This study, integrating pan-cancer bioinformatic analysis with experimental validation, establishes <i>KIF18B</i> as a widely expressed oncogene with significant prognostic value. Our findings in LUAD confirm its crucial role in promoting key malignant phenotypes. Thus, <i>KIF18B</i> emerges as a valuable prognostic biomarker and a potential therapeutic target, not only for LUAD but potentially for a wider array of cancers.

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Publication Details

Journal
Frontiers in Bioscience-Landmark
Published
2026-01-21
DOI
https://doi.org/10.31083/fbl47910
Primary Topic
Microtubule and mitosis dynamics
Type
article
Field-Weighted Citation Impact
0.00
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article

Oncogenic Role of KIF18B Across Human Cancers: A Pan-Cancer Bioinformatic Analysis and Experimental Validation in Lung Adenocarcinoma

Yawen Zhang, Xiantao Xu, Feng Jin, Xiangrong Shao et al.
Frontiers in Bioscience-Landmark
Microtubule and mitosis dynamics
article

Oncogenic Role of KIF18B Across Human Cancers: A Pan-Cancer Bioinformatic Analysis and Experimental Validation in Lung Adenocarcinoma

Yawen Zhang, Xiantao Xu, Feng Jin, Xiangrong Shao, Junli Hou, Wenwen Xu
article en

Abstract

This study, integrating pan-cancer bioinformatic analysis with experimental validation, establishes <i>KIF18B</i> as a widely expressed oncogene with significant prognostic value. Our findings in LUAD confirm its crucial role in promoting key malignant phenotypes. Thus, <i>KIF18B</i> emerges as a valuable prognostic biomarker and a potential therapeutic target, not only for LUAD but potentially for a wider array of cancers.

Frontiers in Bioscience-LandmarkVol. 31(1)
Yangzhou University (CN)
Openalex Percentile: Top 76%
Microtubule and mitosis dynamics
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