Primary endpoints in randomized controlled trials for older adults with cancer: A scoping review
Survival remains the predominant endpoint in confirmatory RCTs involving older adults with cancer, while patient-relevant outcomes are inconsistently incorporated. Addressing these gaps may facilitate more patient-centered trial designs and improve the real-world applicability of research findings for the aging cancer population.
Authors
- Asao Ogawa (ORCID: https://orcid.org/0000-0003-0436-6934)
- Tsuguo Iwatani (ORCID: https://orcid.org/0000-0001-7162-1515)
- Tomonori Mizutani (ORCID: https://orcid.org/0000-0002-9345-1526)
- Funato Sato (ORCID: https://orcid.org/0009-0007-2830-1656)
- Satoshi Kobayashi
- Shimon Tashiro
- Yukari Shimizu
- Hiroshi Yamamoto
- Tetsuya Tsuji
- Kohei Uemura
- Tetsuya Hamaguchi
- Masataka Sawaki
Institutions
- St. Marianna University School of Medicine (JP)
- Kyorin University (JP)
- Tohoku University (JP)
- Keio University (JP)
- Kanagawa Prefectural Hospital Organization (JP)
- National Cancer Centre Japan (JP)
- University of Tokyo Hospital (JP)
- Saitama International Medical Center (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- National Cancer Center Hospital East (JP)
- Nagoya Medical Center (JP)
- Kanagawa Cancer Center
- The University of Tokyo (JP)
- Saitama Medical University (JP)
Publication Details
- Journal
- Journal of Geriatric Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.jgo.2026.102895
- Primary Topic
- Frailty in Older Adults
- Type
- article
- Field-Weighted Citation Impact
- 0.00