Mass Dose Effects in FAP-Directed Imaging: Influence of Administered Dose of [ <sup>68</sup> Ga]Ga-LNTH-1363S on Image Quality
Recent advances in fibroblast activation protein imaging have led to the development of new fibroblast activation protein-targeting radiotracers. This study investigates the mass dose effects of [<sup>68</sup>Ga]Ga-LNTH-1363S on image quality. <b>Methods:</b> In this retrospective evaluation of 39 patients with various oncologic diseases (including breast cancer and sarcoma), different administered mass doses (30, 75, 90, and 100 μg) of [<sup>68</sup>Ga]Ga-LNTH-1363S were visually and quantitatively (blood pool SUV<sub>mean</sub>, lesion SUV<sub>max</sub>, and tumor-to-blood pool ratios [TBRs]) assessed. <b>Results:</b> Lower peptide masses were associated with prominent blood pooling in [<sup>68</sup>Ga]Ga-LNTH-1363S PET imaging and reduced TBRs, whereas higher mass doses yielded superior image quality because of lower mean tracer accumulation in the blood pool and therefore higher TBRs. <b>Conclusion:</b> These observations provide evidence that biodistribution and imaging quality are dependent on the administered mass dose. Further studies are warranted to validate these findings.
Authors
- Niklas Dreher (ORCID: https://orcid.org/0000-0003-2921-8452)
- Gitasha Chand
- Kelly Davis Orcutt
- Lisa Glantschnig
- Marianne Patt (ORCID: https://orcid.org/0000-0001-6492-4104)
- Alexander Dierks
- Jan Baessler
- Martin Trepel
- Karl Sjoestrand
- Bing Bai
- Constantin Lapa
- Johanna S. Enke
Institutions
- Technische Hochschule Augsburg (DE)
- University of Augsburg (DE)
- RaNA Therapeutics (United States) (US)
Publication Details
- Journal
- Journal of Nuclear Medicine
- Published
- 2026-01-29
- DOI
- https://doi.org/10.2967/jnumed.125.271511
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00