tRF-3021a, a tRNA-Ala-TGC derived 3’ fragment, promotes glioblastoma cell invasion, suppresses apoptosis, and is required for normal levels of protein synthesis
tRF-3021a promotes malignant glioma phenotypes, sustains global protein synthesis and prevents spontaneous apoptosis, motivating efforts to evaluate it as a biomarker and therapeutic target.
Authors
- Divya Sahu (ORCID: https://orcid.org/0000-0003-1246-8412)
- Shekhar Ranjan Saha
- Ajay Chatrath (ORCID: https://orcid.org/0000-0003-1309-9612)
- Fatemeh Esmaeili (ORCID: https://orcid.org/0000-0002-1661-8409)
- Pratyush Kumar
- Yoshiyuki Shibata (ORCID: https://orcid.org/0009-0003-9732-5679)
- Anindya Dutta
- Kumarjeet Bannerjee
- Zhangli Su
Institutions
- University of Alabama at Birmingham (US)
- University of Virginia (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-01-28
- DOI
- https://doi.org/10.64898/2026.01.26.701835
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00