Prognostic implications of tumour number in intrahepatic cholangiocarcinoma

Our research provides critical insights into the prognosis of intrahepatic cholangiocarcinoma (ICC) with multiple liver tumours, highlighting the significant impact of tumour multiplicity on survival outcomes. This work addresses the gap in the current staging system, which does not adequately reflect the poor prognosis associated with multiple tumours, especially with the presence of ≥4 tumours. Incorporating these insights into clinical practice could aid in treatment decision-making, risk stratification, and potentially improve patient care and outcomes in ICC management.