Gain-of-Function Variant <i>TRPC6 A404V</i> Is Associated With Doxorubicin-Related Cardiomyopathy

The <i>TRPC6 A404V</i> is a gain-of-function variant that exhibits enhanced activity in the presence of doxorubicin. Therefore, the <i>TRPC6 A404V</i> variant represents a risk factor for anthracycline-induced cardiotoxicity in patients with cancer.

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Publication Details

Journal
Circulation Genomic and Precision Medicine
Published
2026-01-28
DOI
https://doi.org/10.1161/circgen.125.005334
Primary Topic
Ion Channels and Receptors
Type
article
Field-Weighted Citation Impact
0.00
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article

Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy

XIAOJING SUN, Joseph Swaroop Reddy, R X Wang, Hon-Chi Lee et al.
Circulation Genomic and Precision Medicine
Ion Channels and Receptors
article

Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy

XIAOJING SUN, Joseph Swaroop Reddy, R X Wang, Hon-Chi Lee, Ying Wu, Tong Lu
article en

Abstract

The <i>TRPC6 A404V</i> is a gain-of-function variant that exhibits enhanced activity in the presence of doxorubicin. Therefore, the <i>TRPC6 A404V</i> variant represents a risk factor for anthracycline-induced cardiotoxicity in patients with cancer.

Circulation Genomic and Precision MedicineVol. 19(1)
Mayo Clinic (US), Jacksonville College (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US), Wuxi People's Hospital (CN)
Openalex Percentile: Top 74%
Ion Channels and Receptors
DOIOpen Access PDFOpenAlex
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