“When is it late”? Optimal threshold for duration of untreated illness (DUI) to predict SSRI-treatment resistance in individuals with obsessive-compulsive disorder (OCD)
A DUI exceeding about 3.5 years is associated with a substantially lower probability of SSRI response. These data suggest that a duration of untreated illness beyond forty-two months may predict reduced responsiveness to first-line SSRI therapy in OCD, though replication in larger, multicentric samples is warranted.
Authors
- Nicola Rizzo Pesci (ORCID: https://orcid.org/0000-0003-3830-1485)
- Luca Pellegrini (ORCID: https://orcid.org/0000-0002-2855-2865)
- Umberto Albert (ORCID: https://orcid.org/0000-0001-9781-4219)
- Gabriele Di Salvo (ORCID: https://orcid.org/0000-0002-0085-8731)
- Gianluca Rosso
- Giuseppe Maina
Institutions
- Ospedale San Luigi Gonzaga (IT)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- University of Turin (IT)
Publication Details
- Journal
- Journal of Psychiatric Research
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.jpsychires.2026.01.056
- Primary Topic
- Obsessive-Compulsive Spectrum Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00